Key result
Chagas disease with sustained VT is linked to ~60% lower baroreflex sensitivity than indeterminate disease.
Why the study?
Sudden death is the leading cause of death in Chagas disease even in patients with preserved EF, suggesting autonomic modulation contributes to arrhythmia occurrence.
Is impaired baroreflex sensitivity associated with more complex ventricular arrhythmias in patients with Chagas disease?
Cross-Sectional (n=42)
Is impaired baroreflex sensitivity associated with more complex ventricular arrhythmias in patients with Chagas disease?
Absolute Event Rate: 6.09% vs 15.23%
p-value: p=0.01
In Chagas disease, baroreflex sensitivity impairment correlates with the density and complexity of ventricular arrhythmias, independent of ejection fraction.
No takes yet. Share an insight, caveat, or question.
Supports baroreflex sensitivity evaluation for arrhythmic risk in Chagas disease; hypothesis-generating and needs prospective confirmation.
Santos et al. (2014) conducted a cross-sectional in Chagas disease (n=42). Chagas disease with spontaneous sustained ventricular tachycardia vs. Undetermined Chagas disease was evaluated on Baroreflex sensitivity (ms/mm Hg) (p=0.01). Patients with Chagas disease and spontaneous sustained ventricular tachycardia had significantly lower baroreflex sensitivity compared to those with undetermined disease (6.09 vs 15.23 ms/mm Hg; p=0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: