The first isorhapontigenin tetramer, gnetuhainin R (1) and a novel dimeric stilbene, gnetuhainin S (2) were isolated from the lianas of Gnetum hainanense. Their structures were elucidated on the basis of spectroscopic and chemical evidence, especially 2D NMR analysis. The structure of 2 was further supported by X-ray crystallographic analysis. The anti-inflammatory activity of 1 has been tested, and it showed potent activity of histamine receptor antagonism.
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Huang et al. (2002) studied this question.