Key result
Elevated homocysteine is linked to ~19% higher carotid atherosclerosis risk in hypertensive stroke patients.
Why the study?
The correlation between plasma levels of Lp-PLA2, Hcy, CRP, Lp(a), AT-III, TEG parameters, and carotid atherosclerosis in patients with combined hypertension and cerebral infarction was unclear.
Do plasma levels of Lp-PLA2, Hcy, CRP, Lp(a), AT-III, and TEG parameters correlate with carotid atherosclerosis in patients with combined hypertension and cerebral infarction?
Cross-Sectional (n=536)
No
Do plasma levels of Lp-PLA2, Hcy, CRP, Lp(a), AT-III, and TEG parameters correlate with carotid atherosclerosis in patients with combined hypertension and cerebral infarction?
Elevated levels of Lp-PLA2 and Hcy, along with TEG parameter changes, are independently associated with an increased risk of carotid atherosclerosis in patients with combined hypertension and cerebral infarction.
Elevated homocysteine and Lp-PLA2 levels associated with carotid atherosclerosis; hypothesis-generating and should not yet change practice.
Background: To observe the correlation between Lp-PLA2, Hcy, CRP, Lp(a), AT-III, and TEG parameters and carotid atherosclerosis with combined hypertension and cerebral infarction and evaluate their value in risk determination.Methods: Patients with primary hypertension were selected as subjects and divided into 2 groups based on cerebral infarction: simple hypertension group and hypertension combined with cerebral infarction group. The differences of Lp-PLA2, Hcy, CRP, Lp(a), AT-Ⅲ, and TEG were compared. Spearson correlation and multivariate logistic regression model were used to analyze the correlation. A ROC curve was used to analyse the value of a single item and their combination for the determination of carotid AS risk.Results: The levels of single item and CIMT in the hypertension combined with cerebral infarction group were higher, and the values of R, EPL, and LY30 were lower than corresponding indicators in the simple hypertension group. Furthermore, it was found that Lp-PLA2 and Hcy were risk factors. The AUC for Hcy and Lp-PLA2 for the determination the carotid AS risk were larger. Conclusions: The increase or decrease of Lp-PLA2, Hcy, and TEG were important factors influencing the development of carotid AS with combined hypertension and cerebral infarction. The levels of Lp-PLA2, Hcy, and TEG with combined hypertension and cerebral infarction were significantly different from those with simple hypertension and could be used as independent predictive factors for determining carotid AS risk.
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wang et al. (2019) conducted a cross-sectional in Primary hypertension with or without cerebral infarction (n=536). Elevated Lp-PLA2 and Hcy levels vs. Lower levels was evaluated on Carotid atherosclerosis risk (OR 1.190, 95% CI 1.110-1.277, p=<0.001). Elevated plasma levels of homocysteine (OR 1.190) and Lp-PLA2 (OR 1.019) were identified as independent risk factors for carotid atherosclerosis in patients with hypertension and cerebral infarction.
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