Key result
Elevated Lp-PLA2 and Cys C strongly correlate with carotid intima-media thickness in cerebral infarction.
Why the study?
The clinical value of carotid artery color Doppler ultrasonography and plasma levels of Lp-PLA2 and cystatin C in the diagnosis and treatment of arteriosclerotic cerebral infarction required evaluation.
Do carotid artery color Doppler ultrasonography and plasma levels of Lp-PLA2 and Cys C correlate with the diagnosis and severity of arteriosclerotic cerebral infarction?
Case-Control (n=120)
No
Do carotid artery color Doppler ultrasonography and plasma levels of Lp-PLA2 and Cys C correlate with the diagnosis and severity of arteriosclerotic cerebral infarction?
Effect estimate: Kendall correlation factor 0.917
p-value: p=<0.01
Carotid artery color Doppler ultrasonography combined with plasma levels of Lp-PLA2 and Cys C provides valuable clinical markers for the diagnosis and severity assessment of arteriosclerotic cerebral infarction.
Elevated Lp-PLA2 and Cys C levels were associated with carotid thickness in arteriosclerotic cerebral infarction; hypothesis-generating and requires prospective validation before clinical use.
Objective This study was performed to evaluate the clinical application value of carotid artery color Doppler ultrasonography and the plasma levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and cystatin C (Cys C) in the diagnosis and treatment of arteriosclerotic cerebral infarction. Methods Sixty patients with arteriosclerotic cerebral infarction and 60 matched healthy participants were included. The patients were divided into mild, moderate, and severe groups according to their National Institutes of Health Stroke Scale (NIHSS) scores. Carotid artery intima plaque formation and the intima–media thickness (IMT) were observed using carotid artery color Doppler ultrasonography. The correlation between IMT and the Lp-PLA2 or Cys C level was statistically analyzed. Results Patients with arteriosclerotic cerebral infarction had a higher detection rate of carotid plaques, especially unstable plaques, than healthy participants. The plasma levels of Lp-PLA2 and Cys C were elevated in patients with arteriosclerotic cerebral infarction and increased with the NIHSS scores. The plasma levels of Lp-PLA2 and Cys C in patients with arteriosclerotic cerebral infarction were correlated with IMT. Conclusion The combination of carotid artery color Doppler ultrasonography with the Lp-PLA2 and Cys C plasma levels is of great clinical value in the diagnosis and treatment of arteriosclerotic cerebral infarction.
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Huang et al. (2019) conducted a case-control in Arteriosclerotic cerebral infarction (n=120). Arteriosclerotic cerebral infarction vs. Healthy participants was evaluated on Correlation between carotid intima-media thickness and plasma Lp-PLA2 level in patients (Kendall correlation factor 0.917, p=<0.01). In patients with arteriosclerotic cerebral infarction, plasma levels of Lp-PLA2 and Cys C were significantly elevated and strongly correlated with carotid intima-media thickness (Kendall correlation factors 0.917 and 0.873, respectively; P<0.01).
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