Key result
Anterior STEMI with LVEF <50% shows impaired circumferential strain across 15 of 16 LV segments.
Why the study?
Anterior STEMI is associated with severe adverse remodeling and increased mortality, but the function of remote myocardium after anterior STEMI is not well characterized.
Observational (n=48)
Blinded analysis
No
Quantifying end-systolic circumferential strain via CMR feature-tracking reveals depressed remote myocardial function in anterior STEMI, potentially identifying high-risk patients.
Remote strain impairment post-anterior STEMI may signal broader dysfunction; leaves open incremental prognostic value beyond LVEF.
Anterior ST-segment elevation myocardial infarction (STEMI) is associated with severe adverse remodeling and increased mortality rates. In this study, anterior STEMI patients were treated with primary percutaneous coronary intervention and then imaged with cardiac magnetic resonance 1-2 days later. The cine images were analyzed with computational feature-tracking algorithms to assess end-systolic circumferential (ESC) strain. It was found that contractile function is not only depressed in the infarct and border zone regions, but also in the remote myocardium. This is contrary to other types of infarctions where remote myocardium shows enhanced compensatory function. Quantifying ESC could help identify high risk patients.
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Leung et al. (2024) conducted an observational in Anterior ST-segment elevation myocardial infarction (STEMI) (n=48). Anterior STEMI vs. Normal controls was evaluated on End-systolic circumferential (ESC) strain in 16 AHA segments (p=<0.05). Anterior STEMI patients with an ejection fraction < 50% demonstrated significantly reduced end-systolic circumferential strain in 15 of 16 left ventricular segments, including remote myocardium, compared to controls.
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