Retinal tissue obtained from 2 eyes that had been injected with silicone oil for 2 years was stained with monoclonal antibodies against macrophages and studied by light and electron microscopy and energy-dispersive x-ray analysis. Both specimens showed areas with a relatively intact architecture as well as parts with loss of normal structure. In both areas, immunostaining showed single intraretinal macrophages. Energy-dispersive x-ray results clearly demonstrated that some of the intracellular and extracellular vacuoles within the retina represented the storage sites of silicone.
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Eckardt et al. (1992) studied this question.