Key result
Prophylactic flurbiprofen shows no overall link to postoperative leakage or bleeding.
Why the study?
Prophylactic administration of flurbiprofen prevents mesenteric traction syndrome but may increase postoperative bleeding risk after gastrointestinal surgery.
Does prophylactic administration of flurbiprofen increase postoperative leakage or bleeding in patients undergoing gastrointestinal surgery?
Observational (n=188)
No
Does prophylactic administration of flurbiprofen increase postoperative leakage or bleeding in patients undergoing gastrointestinal surgery?
Odds Ratio: 1.57 (95% CI 0.47–5.17)
Absolute Event Rate: 12.5% vs 8.3%
p-value: p=0.45
Prophylactic flurbiprofen for mesenteric traction syndrome during gastrointestinal surgery may increase the risk of postoperative leakage or bleeding in patients who do not develop the syndrome.
May increase leakage/bleeding risk without MTS; hypothesis-generating interaction warrants prospective trials before practice change.
Purpose Mesenteric traction syndrome sometimes occurs during abdominal surgery. Prophylactic administration of flurbiprofen, a non-steroidal anti-inflammatory drug, prevents the development of mesenteric traction syndrome. However, administration of non-steroidal anti-inflammatory drugs for postoperative pain increases the incidence of postoperative bleeding. Our aim was to examine the effect of prophylactic flurbiprofen administration on postoperative leakage or bleeding after gastrointestinal surgery. Methods A retrospective observational study on patients who underwent open or laparoscopic abdominal surgery was conducted. Perioperative, anesthesia and medical records were reviewed. Patients who did (Group F) or did not receive (Group C) prophylactic flurbiprofen administration were compared. Then, Group F (Group FM and Group FC) and Group C (Group CM and Group CC) were each divided into patients who did or did not develop mesenteric traction syndrome, respectively. Results This study included 188 patients (Group FM, 1 patient; Group FC, 31 patients; Group CM, 59 patients; Group CC, 97 patients). Seventeen patients developed postoperative leakage or bleeding. Eleven group CM patients (18.6%), 4 group FC patients (12%), and only 2 group CC patients (2%) developed postoperative leakage or bleeding. Conclusion Prophylactic flurbiprofen administration increased the risk of postoperative leakage or bleeding among patients who did not develop mesenteric traction syndrome.
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Suzuki et al. (2022) conducted an observational in Gastrointestinal surgery (n=188). Prophylactic administration of flurbiprofen vs. No prophylactic administration of flurbiprofen was evaluated on Incidence of postoperative leakage or bleeding (OR 1.57, 95% CI 0.47-5.17, p=0.45). Prophylactic flurbiprofen administration did not significantly affect overall postoperative leakage or bleeding, but increased the risk among patients who did not develop mesenteric traction syndrome.
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