Acute Bilateral Uveitis Following COVID-19 Vaccination: Case Reports

Introduction:The development of the COVID-19 vaccines occurred promptly, and we are still learning about their side effects.Therefore, it is important to report possible medical associations to them.Case 1: A 21-year-old female, with no significant medical history for this event, diagnosed with bilateral acute anterior uveitis three days after receiving the Pfizer-Biontech COVID-19 vaccine.An aggravation of the disease was observed after the administration of the second dose.Case 2: A 70-year-old male, with no relevant medical history, presenting with a bilateral anterior uveitis after receiving the Pfizer-Biontech COVID-19 vaccine 3 to 4 weeks before.A macular edema of the right eye developed later in the course of the disease.Discussion: Vaccines can induce uveitis and other ocular inflammatory conditions through different possible mechanisms.In both cases we reported here, the temporal relationship between the onset of the symptoms and the administration of the vaccines makes this medication a possible cause for the ocular manifestation.