Key result
Experimental inoculation of newborn piglets with the Korean porcine deltacoronavirus strain KNU16-07 induced acute enteritis with watery diarrhea and viral shedding, demonstrating its enteropathogenicity.
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The Korean PDCoV strain KNU16-07 was successfully isolated, cultivated, and shown to cause acute enteritis and watery diarrhea in piglets while maintaining genetic stability over 30 passages.
Porcine deltacoronavirus (PDCoV) has emerged in several pig-raising countries and has been a causative pathogen associated with diarrheal diseases in South Korea since 2014. In the present study, we were able to isolate and cultivate a Korean PDCoV strain (KNU16-07) in cell culture and investigate its pathogenicity. PDCoV-inoculated piglets showed watery diarrhea accompanied by acute enteritis in the natural host. Sequencing analysis demonstrated the genetic stability of KNU16-07 for at least thirty serial passages.
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Jang et al. (2018) studied Porcine deltacoronavirus infection (n=4). Porcine deltacoronavirus strain KNU16-07 vs. Cell culture media (placebo) was evaluated on Clinical signs of acute enteritis (watery diarrhea, vomiting) and viral shedding. Experimental inoculation of newborn piglets with the Korean porcine deltacoronavirus strain KNU16-07 induced acute enteritis with watery diarrhea and viral shedding, demonstrating its enteropathogenicity.
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