Key result
RCT tests HIIT plus Mediterranean diet for improving cardiorespiratory fitness after myocardial infarction.
Why the study?
The comparative effects of different volumes of high-intensity interval training combined with Mediterranean diet recommendations on clinical and functional outcomes after myocardial infarction are not established.
Does a combined high-intensity aerobic interval training program and Mediterranean diet improve cardiorespiratory fitness, biomarkers, and quality of life in patients after type 1 myocardial infarction?
RCT (n=177)
Open-label, blinded-endpoint
1:1:1 block and stratified randomization
No
Does a combined high-intensity aerobic interval training program and Mediterranean diet improve cardiorespiratory fitness, biomarkers, and quality of life in patients after type 1 myocardial infarction?
This study protocol outlines a randomized controlled trial to evaluate the effects of high- and low-volume high-intensity interval training combined with a Mediterranean diet in patients after type 1 myocardial infarction.
Planned RCT tests combined HIIT plus Mediterranean diet on CRF post-MI; leaves open efficacy until results emerge.
BACKGROUND: Exercise therapy has long been used for rehabilitation purposes after myocardial infarction (MI) and the benefit of regular physical exercise is also well-established. High-intensity interval training (HIIT) has been proposed to be more effective than continuous exercise for improving exercise capacity and health-related adaptations to low-volume (LV) and HIIT are also known. Furthermore, the Mediterranean diet (Mediet) has been widely reported to be a model of healthy eating for its contribution to a favorable health status and a better quality of life, reducing overall mortality. This study will investigate the effects of different HIIT programs (high-volume [HV] vs LV) and Mediet recommendations in clinical condition, cardiorespiratory fitness, biomarkers, ventricular function, and perception of quality of life after MI, and compared to an attention control group that is recommended to Mediet and physical activity without supervision sessions. METHODS/DESIGN: In this randomized controlled trial, cardiorespiratory fitness, anthropometry, central and peripheral cardiovascular variables, biochemical and nutritional condition, and quality of life will be assessed before and after 16 weeks of intervention in 177 participants diagnosed with MI type 1. All participants will be randomly (1:1:1) assigned to the attention control group or two exercise groups (Mediet recommendations plus supervised aerobic exercise two days/week: (1) HV (40 min) HIIT group and (2) LV (20 min) HIIT group. DISCUSSION: This study will be the first clinical trial comparing the effects of two different volumes of HIIT programs with Mediet recommendations for people after MI. The results of this study will provide good evidence for physical rehabilitation in this population. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02876952 . Registered on 24 August 2016.
No takes yet. Share an insight, caveat, or question.
Maldonado‐Martín et al. (2018) conducted an RCT in Myocardial infarction type 1 (n=177). High-intensity interval training (HV-HIIT or LV-HIIT) plus Mediterranean diet recommendations vs. Attention control (Mediterranean diet and physical activity recommendations without supervision) was evaluated on Cardiorespiratory fitness (VO2peak). High-intensity interval training and Mediterranean diet recommendations will be evaluated for their effects on cardiorespiratory fitness in 177 patients after myocardial infarction in this planned randomized controlled trial.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: