Key result
TTN variants show no association with disease severity or clinical outcomes in dilated cardiomyopathy.
Why the study?
The prevalence and genotype-phenotype correlations of genetic variants in dilated cardiomyopathy among different ethnic cohorts, including Chinese patients, remain unclear.
Observational
In Chinese patients with dilated cardiomyopathy, TTN variants are common but do not appear to correlate with specific differences in disease severity or clinical outcomes compared to non-carriers.
TTN status should not guide prognosis or therapy in Chinese DCM; leaves open whether ethnicity modifies variant effects seen elsewhere.
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Yeh et al. (2019) conducted an observational in Dilated cardiomyopathy (DCM). TTN variants vs. non-carriers was evaluated on Disease severity, clinical outcome and reversibility of ventricular function. TTN variants in Chinese patients with dilated cardiomyopathy were not associated with differences in disease severity, clinical outcome, or reversibility of ventricular function versus non-carriers.
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