January 1, 2005Journal of Spinal Cord Medicine
C-Reactive Protein, Metabolic Syndrome, and Insulin Resistance in Individuals With Spinal Cord Injury
Key result
Insulin resistance in spinal cord injury is linked to ~92% higher mean hsCRP levels.
- P<0.05
- n=93
Why the study?
High-sensitivity C-reactive protein (hsCRP) may indicate elevated cardiovascular risk, but its relationship with insulin resistance and metabolic syndrome in individuals with spinal cord injury was unclear.
Is high-sensitivity C-reactive protein associated with insulin resistance and metabolic syndrome in individuals with spinal cord injury?
Population
93 individuals with spinal cord injury, mean age 50.2 +/- 13 years
Comparison
Individuals with insulin resistance and/or metabolic syndrome vs those without
Design
Cross-sectional analysis
Authors
Discussion
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Implication
May support hsCRP for cardiovascular risk stratification in spinal cord injury; hypothesis-generating and requires prospective validation.
Study Design
Type
Cross-Sectional (n=93)
Structured PICO
Is high-sensitivity C-reactive protein associated with insulin resistance and metabolic syndrome in individuals with spinal cord injury?
P
Population
93 individuals with spinal cord injury (mean age 50.2 years) assessed for hsCRP, insulin resistance, and metabolic syndrome.
O
Outcome
Relationship between high-sensitivity C-reactive protein (hsCRP) and insulin resistance and metabolic syndromesurrogate
Main Result
Absolute Event Rate: 4.29% vs 2.24%
p-value: p=< 0.05
In individuals with spinal cord injury, elevated hsCRP is associated with insulin resistance and metabolic syndrome, suggesting it may be a useful marker for cardiovascular risk in this population.
Cite This Study
Lee et al. (2005) conducted a cross-sectional in Spinal cord injury (n=93). Fasting insulin resistance vs. No insulin resistance was evaluated on mean hsCRP (mg/L) (p=< 0.05). Fasting insulin resistance in individuals with spinal cord injury was associated with significantly higher mean hsCRP compared to those without insulin resistance (4.29 vs 2.24 mg/L; P < 0.05).