Key result
Administration of cyclobenzaprine in two postoperative patients already receiving proserotoninergic drugs induced severe serotonin syndrome that resolved within 3 days of discontinuation.
Why the study?
Does cyclobenzaprine induce serotonin syndrome in postoperative patients receiving other proserotoninergic drugs?
Case Report (n=2)
Does cyclobenzaprine induce serotonin syndrome in postoperative patients receiving other proserotoninergic drugs?
Cyclobenzaprine can induce potentially lethal serotonin syndrome when combined with other proserotoninergic drugs, requiring extreme caution and close monitoring.
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Cyclobenzaprine may precipitate severe serotonin syndrome with concurrent serotonergic agents; leaves open prospective perioperative safety data.
Keegan et al. (2006) conducted a case report in Serotonin syndrome (n=2). Cyclobenzaprine was evaluated on Development of serotonin syndrome (autonomic instability and severe agitation). Administration of cyclobenzaprine in two postoperative patients already receiving proserotoninergic drugs induced severe serotonin syndrome that resolved within 3 days of discontinuation.
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