RXRβ gene polymorphisms and the genetic predisposition to type 2 diabetes mellitus in South China

Aims: To figure out the correlation between RXRβ gene polymorphisms and genetic predisposition to Type 2 Diabetes Mellitus (T2DM) in Chinese Han people from South China. Methods and Material: In our case-control study, 1092 Chinese T2DM patients were included at the 10 hospitals from Shenzhen, Dongguan, Maoming, Zhanjiang, and Shaoguan of Guangdong Province, from November 2011 to October 2013. Moreover, 1092 healthful controls were also subsumed after body checks in the above hospitals. Extraction of genomic DNA from peripheral blood. Subsequently, single-nucleotide polymorphisms (SNPs) rs2744537 and rs2076310 were genotyped by the SNPscanTM kit. Results: We not observed statistical differences at allele and genotype distributional frequencies of SNPs rs2744537 and rs2076310 between the two groups. Moreover, no statistical differences were also observed at the distributional frequencies of all genetic models between the two groups. In linkage disequilibrium analysis, the rs2076310 and rs2744537 of RXRβ gene have linkage disequilibrium. However, there were no statistical differences in the distributional frequencies of all Haplotypes by the haplotype analysis. Conclusions: The genetic predisposition to T2DM may be not associated with SNPs rs2744537 and rs2076310 of RXRβ gene in the Chinese Han population from South China.