Key result
Antiplatelet therapy is linked to ~24% lower sudden cardiac death risk in LV dysfunction.
Why the study?
The association of antiplatelet and anticoagulant therapy with the risk of sudden cardiac death in patients with moderate to severe left ventricular systolic dysfunction was unclear.
Does antiplatelet or anticoagulant therapy reduce the risk of sudden cardiac death in patients with moderate to severe left ventricular systolic dysfunction resulting from coronary artery disease?
Population
6,797 participants with moderate to severe left ventricular systolic dysfunction from SOLVD prevention and treatment trials
Comparison
Antiplatelet and anticoagulant monotherapy vs no antithrombotic therapy
Design
Retrospective cohort analysis using multivariate Cox proportional-hazards modeling
Authors
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In patients with moderate to severe left ventricular systolic dysfunction due to coronary artery disease, antiplatelet and anticoagulant therapies are independently associated with a reduced risk of sudden cardiac death.
Cohort (n=6,797)
Does antiplatelet or anticoagulant therapy reduce the risk of sudden cardiac death in patients with moderate to severe left ventricular systolic dysfunction resulting from coronary artery disease?
Relative Risk: 0.76 (95% CI 0.61–0.95)
In patients with moderate to severe left ventricular systolic dysfunction due to coronary artery disease, antiplatelet and anticoagulant therapies are independently associated with a reduced risk of sudden cardiac death.
Dries et al. (1997) conducted a cohort in Congestive Heart Failure (n=6,797). Antiplatelet and anticoagulant therapy vs. No antiplatelet or anticoagulant therapy was evaluated on sudden cardiac death (RR 0.76, 95% CI 0.61-0.95). Antiplatelet therapy (RR 0.76; 95% CI 0.61-0.95) and anticoagulant therapy were each independently associated with a reduced risk of sudden cardiac death in patients with left ventricular dysfunction.
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