Cerebral Thrombosis in Smokers' Polycythemia

Brief Reports1 June 1985Cerebral Thrombosis in Smokers' PolycythemiaDONALD C. DOLL, M.D., BERNARD R. GREENBERG, M.D.DONALD C. DOLL, M.D., BERNARD R. GREENBERG, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-6-786 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSmokers' polycythemia is characterized by erythrocytosis, a raised concentration of carboxyhemoglobin, and a normal or reduced plasma volume due to tobacco smoking (1, 2). The polycythemia may be absolute (elevated red cell mass) or relative (normal red cell mass). Vascular occlusive episodes may occur in patients with polycythemia vera (3) or spurious polycythemia (4), and cerebral thrombosis has also rarely been reported in patients with secondary polycythemia due to congenital cyanotic heart disease. However, there are no reports of cerebral thrombosis associated with polycythemia resulting from smoking. We describe the cases of two patients with smokers' polycythemia who had a...References1. SMITH J and LANDAW S. Smokers' polycythemia. N Engl J Med. 1978;298:6-10. CrossrefMedlineGoogle Scholar2. SAGONE A and BALCERZAK S. Smoking as a cause of erythrocytosis. Ann Intern Med. 1975;82:512-5. LinkGoogle Scholar3. PEARSON T and WETHERLEY-MEIN G. Vascular occlusive episodes and venous haematocrit in primary proliferative polycythaemia. Lancet. 1978;2:1219-22. CrossrefMedlineGoogle Scholar4. WEINREB N and SHIH C. Spurious polycythemia. Semin Hematol. 1975;12:397-407. MedlineGoogle Scholar5. BRODY J and COBURN R. Carbon monoxide-induced arterial hypoxemia. Science. 1969;164:1297-8. CrossrefMedlineGoogle Scholar6. GOLDE D, HOCKING W, KOEFFLER H, and ADAMSON J. Polycythemia: mechanisms and management. Ann Intern Med. 1981;95:71-87. LinkGoogle Scholar7. HUMPHREY P, DU BOULAY G, and MARSHALL J. Cerebral blood-flow and viscosity in relative polycythaemia. Lancet. 1979;2:873-7. CrossrefMedlineGoogle Scholar8. THOMAS D, DU BOULAY G, and MARSHALL J. Cerebral blood-flow in polycythaemia. Lancet. 1977;2:161-3. CrossrefMedlineGoogle Scholar9. THOMAS D, MARSHALL J, and RUSSELL R. Effect of haematocrit on cerebral blood-flow in man. Lancet. 1977;2:941-3. CrossrefMedlineGoogle Scholar10. HUMPHREY P, MICHAEL J, and PEARSON T. Red cell mass, plasma volume and blood volume before and after venesection in relative polycythaemia. Br J Haematol. 1980;46:435-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DONALD C. DOLL, M.D.; BERNARD R. GREENBERG, M.D.Affiliations: Veterans Administration Medical Centers Phoenix and Tucson, Arizona PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCyanotic Congenital Heart Disease: A Multisystem DisorderInternal Carotid Artery Occlusion In a Patient With Malignant Peritoneal Mesothelioma: Is It a Sign of Malignancy-Related Thrombosis?ArterioskleroseHematologic disorders associated with ischemic strokeUpdate on stroke risk factorsApparent polycythaemia: diagnosis, pathogenesis and managementThromboembolic complications of polycythemia: Polycythemia vera versus smokers' polycythemiaApparent polycythaemiaHematologic disorders and ischemic stroke. A selective review.Akuter Myokardinfarkt bei durch Nikotinabusus induzierter ErythrozytosePoliglobulias secundarias hipoxicasErythrocytosisPseudopolycythaemia and coeliac disease.Hematologic EmergenciesReferences 1 June 1985Volume 102, Issue 6Page: 786-787KeywordsAttentionCarboxyhemoglobinCardiovascular therapyHematology and oncologyPlasma volumePolycythemiaPolycythemia veraThrombosis ePublished: 1 December 2008 Issue Published: 1 June 1985 PDF downloadLoading ...