Key result
Wedged pulmonary artery catheter blood cytology enables ante-mortem diagnosis of pulmonary tumour thrombotic microangiopathy.
Why the study?
Pulmonary tumour thrombotic microangiopathy is a rare malignancy complication often diagnosed only at autopsy due to rapid hypoxaemia deterioration.
Case Report (n=1)
Blood cytology from a wedged pulmonary artery catheter can provide a valuable ante-mortem diagnostic tool for pulmonary tumour thrombotic microangiopathy in cancer patients with rapidly progressing pulmonary hypertension.
May support ante-mortem PTTM diagnosis via wedged catheter cytology in select cases; hypothesis-generating and requires prospective validation.
Pulmonary tumour thrombotic microangiopathy (PTTM) resulting in fatal pulmonary hypertension is a rare complication of malignancy. Patients with PTTM generally suffer rapid deterioration of hypoxaemia, and a diagnosis is often only made at autopsy. We report a case of extramammary Paget's disease associated with PTTM. An ante-mortem diagnosis was made based on cytology of blood aspirated from a pulmonary artery catheter in a wedged position. Together with a review of the literature, this case highlights the potential diagnostic value of blood cytology in patients with cancer with rapidly progressing pulmonary hypertension.
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Banno et al. (2016) conducted a case report in Pulmonary tumour thrombotic microangiopathy (PTTM) and extramammary Paget's disease (n=1). Cytology of blood aspirated from a pulmonary artery catheter in a wedged position was evaluated on Ante-mortem diagnosis of PTTM. Ante-mortem diagnosis of pulmonary tumour thrombotic microangiopathy was successfully made using cytology of blood aspirated from a wedged pulmonary artery catheter.
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