Key result
Pulmonary microvascular cytology enables antemortem diagnosis of pulmonary tumor thrombotic microangiopathy in urothelial cancer.
Why the study?
Pulmonary tumor thrombotic microangiopathy is very difficult to diagnose before death, limiting opportunities for timely diagnosis and treatment.
Pulmonary microvascular cytology may provide a rare opportunity for the antemortem diagnosis of pulmonary tumor thrombotic microangiopathy.
May prompt cytology in suspected PTTM with cancer; leaves open whether it improves outcomes.
PTTM (Pulmonary tumor thrombotic microangiopathy) is very difficult to diagnose before death. We report a case of urothelial carcinoma of the urinary bladder associated with PTTM in which an antemortem diagnosis by PMC (pulmonary microvascular cytology). PMC may represent the only chance for diagnosis and achievement of remission in PTTM.
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Yamakawa et al. (2015) studied this question. Pulmonary microvascular cytology enabled the antemortem diagnosis of pulmonary tumor thrombotic microangiopathy in a patient with urothelial carcinoma, offering a chance for remission.
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