Key result
Intervention triples the odds of favorable functional outcomes versus conservative management in very elderly patients.
Why the study?
Outcomes of ruptured intracranial aneurysms in patients aged 80 years or older and the impact of treatment strategies on these outcomes were not well characterized.
Does interventional treatment improve functional outcomes and reduce mortality in patients aged >=80 years with ruptured intracranial aneurysms compared to conservative management?
Meta-Analysis (n=14,469)
Yes
Does interventional treatment improve functional outcomes and reduce mortality in patients aged >=80 years with ruptured intracranial aneurysms compared to conservative management?
Odds Ratio: 3.18
Absolute Event Rate: 28.6% vs 9.2%
Interventional treatment for ruptured intracranial aneurysms in very elderly patients (>=80 years) is associated with improved functional outcomes and reduced mortality compared to conservative management, especially in those with good initial clinical grades.
May inform prognosis in octogenarians with aSAH; leaves open optimal treatment selection pending higher-level evidence.
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Zeiser et al. (2026) conducted a meta-analysis in Ruptured intracranial aneurysms (n=14,469). Interventional treatment (surgical clipping or endovascular treatment) vs. Conservative management was evaluated on Favorable functional outcome (OR 3.18). Interventional treatment significantly improved the odds of a favorable outcome compared to conservative management (28.6% vs 9.2%; OR 3.18) and reduced mortality (OR 0.16) in very elderly patients.
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