What is the clinical evidence from this study?

Study design: Case Report. Population: Incomplete Kawasaki disease (n=1). Intervention: Early treatment (intravenous immunoglobulin, infliximab). Primary outcome: Coronary aneurysm progression.

What does this research mean for the field?

Incomplete Kawasaki disease can rapidly progress to diffuse giant coronary artery aneurysms despite early and multiple anti-inflammatory treatments. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To describe the rapid development of giant coronary artery aneurysms in a young child with incomplete Kawasaki disease despite prompt treatment.

October 1, 2026JACC Case ReportsOpen Access

Incomplete Kawasaki Disease With Rapid Coronary Aneurysm Progression

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Key result

Early IVIG and infliximab fail to prevent diffuse giant coronary aneurysms in incomplete Kawasaki disease.

Why the study?

The incidence and progression risk of coronary artery aneurysms in incomplete Kawasaki disease are unclear despite similar or higher coronary lesion risk compared to complete disease.

Population

A 2-year-old boy with incomplete Kawasaki disease

Design

Case report

Authors

DBDaniela BenitezUniversidad Internacional del Ecuador HMHimanshu MeenaMiami Children's Hospital JMJose Ugarriza MendozaMiami Children's Hospital

Discussion

Member takes

Implication

Rapid progression to giant aneurysms can occur in incomplete Kawasaki disease despite early therapy; this case leaves open optimal monitoring and escalation strategies.

Key Points

To describe the rapid development of giant coronary artery aneurysms in a young child with incomplete Kawasaki disease despite prompt treatment.
Clinical case evaluation of a 2-year-old boy presenting with incomplete Kawasaki disease and an initially normal echocardiogram.
Serial echocardiographic monitoring and treatment escalation using intravenous immunoglobulin, infliximab, aspirin, and systemic anticoagulation.
Follow-up imaging revealed diffuse giant coronary artery aneurysms across the left anterior descending, right coronary, and left circumflex arteries despite early initial therapy.
The patient required salvage anti-inflammatory treatment with infliximab alongside long-term dual antithrombotic management.

Study Design

Type

Case Report (n=1)

Structured PICO

Population

A 2-year-old boy with incomplete Kawasaki disease who developed rapid coronary aneurysm progression despite early treatment.

Intervention

Multiple anti-inflammatory therapies (intravenous immunoglobulin, infliximab) and lifelong antithrombotic management with aspirin and anticoagulation

Outcome

Progression to severe coronary involvement (diffuse giant coronary artery aneurysms in the left anterior descending artery, right coronary artery, and left circumflex artery)

Incomplete Kawasaki disease can rapidly progress to giant coronary aneurysms despite early treatment and normal initial echocardiography, highlighting the critical need for serial imaging.

Cite This Study

Benitez et al. (2026) conducted a case report in Incomplete Kawasaki disease (n=1). Early treatment (intravenous immunoglobulin, infliximab) was evaluated on Coronary aneurysm progression. A 2-year-old boy with incomplete Kawasaki disease rapidly developed diffuse giant coronary artery aneurysms despite early treatment with intravenous immunoglobulin and infliximab.

synapsesocial.com/papers/6abda8f14d657f10339f949b https://doi.org/10.1016/j.jaccas.2026.110344

Topics

Coronary artery disease

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Implication

Rapid progression to giant aneurysms can occur in incomplete Kawasaki disease despite early therapy; this case leaves open optimal monitoring and escalation strategies.

Incomplete Kawasaki Disease With Rapid Coronary Aneurysm Progression

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Topics

Incomplete Kawasaki Disease With Rapid Coronary Aneurysm Progression

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider