Key result
Anesthesia and surgery unpredictably alter drug PK/PD, requiring close postoperative vital sign monitoring.
Why the study?
Anaesthesia and surgery can alter drug compliance, pharmacokinetics, and pharmacodynamics, but quantitative effects on drug action are not well characterized.
Anaesthesia and surgery can unpredictably alter drug pharmacokinetics and pharmacodynamics, necessitating careful postoperative monitoring of vital signs.
May prompt closer postoperative surveillance for drug effects; leaves open identification of high-risk interactions pending prospective data.
Anaesthesia and surgery can influence the action of another drug by changing drug compliance, the pharmacokinetics or the pharmacodynamics. Failure of drug compliance after surgery may result in an acute abstinence syndrome, as for example tachycardia and hypertension if propranolol is discontinued abruptly. Changes in drug absorption result usually in therapeutic failure. Altered distribution or clearance may result in toxicity. Pharmacodynamics are much more important than pharmacokinetics but there is less information on the effect of anaesthesia and surgery on drug action. Changes are usually predictable qualitatively but not quantitatively and therefore observation and monitoring of the effect of drugs on vital signs form a necessary part of postoperative care.
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Nimmo et al. (1988) conducted a review in Anaesthesia and surgery effects on drug action. Anaesthesia and surgery was evaluated. Anaesthesia and surgery can unpredictably alter the pharmacokinetics and pharmacodynamics of other drugs, necessitating careful postoperative observation and monitoring of vital signs.
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