Key result
Arterial wall imaging reliably characterizes plaque and tracks therapeutic impact on atherosclerosis progression.
Why the study?
Despite the benefit of medical therapies, a substantial residual risk of cardiovascular events remains, motivating evaluation of imaging techniques to assess novel anti-atherosclerotic therapies.
Can arterial wall imaging be used to evaluate the impact of novel anti-atherosclerotic therapies on disease progression?
Can arterial wall imaging be used to evaluate the impact of novel anti-atherosclerotic therapies on disease progression?
Arterial wall imaging modalities can provide early assessment of the impact of novel anti-atherosclerotic agents on plaque progression.
BACKGROUND: Despite the benefit of medical therapies, there remains a substantial residual risk of cardiovascular events. Atherosclerosis imaging has been used to assess new therapies. SCOPE: A selective review of current imaging techniques used to evaluate novel anti-atherosclerotic therapies. FINDINGS: Noninvasive and invasive arterial wall imaging permits characterization of the quantity and composition of atherosclerotic plaque. Serial imaging enables assessment of the impact of therapies on the natural history of disease progression. CONCLUSION: Both noninvasive and invasive imaging modalities can be used in development programs to provide an early assessment of the impact of novel anti-atherosclerotic agents.
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Uno et al. (2010) conducted a review in Atherosclerosis. Arterial wall imaging was evaluated. Noninvasive and invasive arterial wall imaging permits characterization of atherosclerotic plaque and assessment of the impact of therapies on disease progression.
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