Outcomes of Laser Interstitial Thermal Therapy-Augmented Surgery in the Management of Subcortical Glioblastoma.

BACKGROUND AND OBJECTIVES: Subcortical glioblastomas present surgical challenges owing to their proximity to critical anatomy. In this study, we assessed the utility of laser interstitial thermal therapy (LITT) in the management of subcortical glioblastomas. METHODS: Clinical outcomes were evaluated in 80 consecutive patients with subcortical glioblastoma (isocitrate dehydrogenase wild-type, H3K27 nonmutant) treated surgically between 2017 and 2025. During this time period, LITT was increasingly incorporated into stereotactic needle biopsy (SNB) and surgical resection (SR) workflows, enabling comparisons between SNB vs SNB + LITT and between SR only vs planned subtotal resection (STR) + LITT. RESULTS: < .001). CONCLUSION: Our results support incorporating LITT as a staged procedure into planned STR or in conjunction with SNB in the management of subcortical glioblastoma. Postoperative motor deficit is associated with poor survival outcomes.