Outside Back Cover: Decoding Atypical G‐Quadruplexes and Their Interactome in Liquid Biopsies via Integrated Electroanalytical–Proteomic Technologies

In the Research Article e3768019, Víctor Ruiz-Valdepeñas Montiel, Rodrigo Barderas, Susana Campuzano, and co-workers report a versatile electroanalytical platform for the global profiling of G-quadruplexes (G4s) in cancer biopsies. By integrating magnetic immunocapture with advanced proteomics, the platform enables selective isolation of endogenous G4-forming DNA regions, reveals stage-dependent remodelling of the plasma G4 interactome, and identifies a prognostic G4-binding protein. Image by Víctor Ruiz-Valdepeñas Montiel.