The protein folding problem, characterized by Levinthal’s paradox, complex energy funnels, and co-translational kinetic trapping, is fundamentally unified within the Seonggil Matrix Theory (SMT) and Rough Operator Algebra (ROA). By redefining the conformational search space as a topological phase separation guided by the Seonggil Critical Horizon, the astronomical 32N degrees of freedom collapse into a deterministic polynomial-time tensor projection. Static predictions (e.g., AlphaFold) are formally subsumed as infinite-time steady-state eigenvectors of this dynamic topological tensor flow.
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Seonggil Lee (2026) studied this question.
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