The phenomenon of enzymes exceeding the fundamental diffusion limit (kcat/KM ≳109 M⁻¹s{−1}) is fully resolved through the integration of the Constructive Electrostatic Quantum-Dynamic Catalysis (CEQDC) framework with Seonggil Matrix Theory (SMT) and Rough Operator Algebra (ROA). By mapping electrostatic preorganization to a topological gauge field and treating quantum tunneling as a Sashangmugak dimensional collapse at the Seonggil Critical Horizon, the classical catalytic limits are algebraically transcended.
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Seonggil Lee (2026) studied this question.
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