Association of Age with Changes in Renal Function, Biochemical Parameters, and Electrolytes During Surgery

Background: Surgery and anesthesia can affect how the kidneys work and the body’s chemistry, in people who already have kidney problems. The patient’s age is a factor that can influence how well the kidneys work and how they react to the stress of surgery. So, checking the patients’ blood work before and after surgery can give doctors information about how the kidneys are doing during this time. Surgery and anesthesia can cause changes in function, and the body’s chemistry and age can affect renal function and the response to surgery. Aim: The aim of this study is to investigate differences in biochemical parameters among different age groups of patients undergoing general anesthesia and to evaluate changes in these parameters before and after surgery. Methods: A total of 75 patients were part of the study. Divided into three age groups: 45 to 54 years (n=30) 55 to 64 years (n=30) and 65 years and older (n=15.). Serum urea, creatinine, acid, albumin, potassium, sodium and chloride were checked before and after surgery. One-way analysis of variance (ANOVA) was used to compare the results across the three age groups. A P value less than 0.05 was considered significant. Results: We saw some changes after surgery in serum urea, creatinine, uric acid and albumin levels. The urea level went up from 41.10 to 43.10 mg/dL, which's a significant increase. This change is important because it happened after surgery. The creatinine level also went up from 1.16 to 1.32 mg/dL, which is also significant. The uric acid level increased from 5.46 to 5.66 mg/dL. On the hand the albumin level went down from 3.72 to 3.64 g/dL. We did not see any significant changes in potassium, sodium or chloride levels after surgery. When we looked at age groups, we found that the creatinine level before surgery was different in each group. The 55–64-year age group had the creatinine level, before surgery. This difference is significant. Serum urea and serum creatinine and uric acid and albumin levels are all important to consider when looking at surgery results. Conclusion: The study shows that the time around the operation had an effect on some important blood tests, like urea, creatinine, uric acid and albumin levels. The biggest difference with age was seen in the creatinine levels before the operation, which suggests that age is connected to how the kidneys are working before the surgery in the patients who were studied.