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Interfacing biologic material with foreign substances is a problem common to all implantable devices. This paper discusses these problems with respect to degradation of the material used in fabrication and the body's reaction to the foreign substance. The requirements dictate the type of tissue reaction sought and this in turn determines the base material. A nonreactive material may be ideal for one set of needs but tissue reactivity would be required for another. The specialized tissue “blood” is given special emphasis.
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Ghidoni et al. (1971) studied this question.
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