Key result
Early menopause linked to ~61% higher TLR risk after PCI in women.
Why the study?
Early menopause has been associated with higher cardiovascular risk, but its impact on clinical outcomes after PCI in women was unclear.
Does early menopause increase the risk of adverse cardiovascular outcomes in women undergoing PCI?
Cohort
Does early menopause increase the risk of adverse cardiovascular outcomes in women undergoing PCI?
In women undergoing PCI, early menopause (≤46 years old) is associated with a significantly higher risk of MACE, driven primarily by target lesion revascularization.
May flag higher-risk women for PCI; leaves open independent prognostic value beyond risk factors.
Early menopause has been found to be associated with higher risk of cardiovascular disease. Our objective was to investigate the impact of early menopause on clinical outcomes for women undergoing percutaneous coronary intervention (PCI). We observed female patients with coronary artery disease (CAD) undergoing PCI and found that women with early menopause (≤46 years old) were more likely to have CAD risk factors and more severe coronary lesions. During the 18-month follow-up, early menopause was associated with similar risk of death and myocardial infarction but higher risk of target lesion revascularization (TLR; 7.8% vs 5.3%, P = .003) and major adverse cardiovascular events (MACEs; 11.3% vs 9.0%, P = .007). After adjustment, early menopause was an independent risk factor for 18-month MACEs (hazard ratio [HR], 1.54; 95% confidence interval [CI] 1.18-2.00) and TLR (HR 1.61; 95% CI 1.21-2.13). In conclusion, for women undergoing PCI, early menopause is associated with higher risk of MACE, which is mainly driven by risk of TLR.
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Zhang et al. (2015) conducted a cohort in Coronary artery disease undergoing percutaneous coronary intervention. Early menopause (≤46 years old) vs. No early menopause was evaluated on Target lesion revascularization (TLR) (HR 1.61, 95% CI 1.21-2.13, p=.003). Early menopause (≤46 years old) in women undergoing PCI was associated with a higher risk of target lesion revascularization at 18 months (7.8% vs 5.3%; HR 1.61; 95% CI 1.21-2.13).
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