Key result
Temporary DAPT interruption after DES links to a ~1.0% incidence of thrombosis or MI.
Why the study?
The outcomes of patients undergoing temporary or permanent suspension of dual antiplatelet therapy after drug-eluting stent implantation remain to be clearly described in real-world practice.
Does temporary or permanent suspension of dual antiplatelet therapy increase the risk of stent thrombosis or acute myocardial infarction in patients after drug-eluting stent implantation?
Population
5,681 patients receiving coronary drug-eluting stents from a single-center registry
Comparison
Temporary or permanent suspension of DAPT vs uninterrupted DAPT
Design
Single-center cohort study
Follow-up
1,108 ± 446 days
Authors
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DAPT withdrawal post-DES may raise ST/AMI risk in real-world cohorts; leaves open optimal duration and predictors for prospective study.
Cohort (n=5,681)
No
Does temporary or permanent suspension of dual antiplatelet therapy increase the risk of stent thrombosis or acute myocardial infarction in patients after drug-eluting stent implantation?
Absolute Event Rate: 1% vs 0.43%
In real-world practice, the rates of stent thrombosis or acute myocardial infarction following temporary or permanent cessation of DAPT after DES implantation are low, with high-risk patients more likely to remain on uninterrupted therapy.
Kovacic et al. (2012) conducted a cohort in Drug-eluting stent implantation (n=5,681). Temporary or permanent suspension of dual antiplatelet therapy vs. Uninterrupted dual antiplatelet therapy was evaluated on Stent thrombosis (ST) and/or acute myocardial infarction (AMI). Temporary suspension of DAPT after DES implantation had a 1.0% rate of stent thrombosis or AMI, and permanent cessation a 0.1-0.2% annual rate, compared to 0.43% annually for uninterrupted DAPT.
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