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Herein, we demonstrate that arynes can be generated and trapped efficiently through mechanically assisted microscale mixing on a standard vortex mixer. Brief vortex agitation enables ultra-fast generation and interception of these highly reactive intermediates with N-, O-, S-, and C-nucleophiles within 1 min, therefore providing a low-energy-solvent minimized approach for aryl functionalization without the need for inert atmosphere, heating, or bulk solvent.
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Breinsperger et al. (2026) studied this question.
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