Why Is the Target Missed in Psoriatic Arthritis, and How Can We Disentangle the Underlying Drivers?

Psoriatic arthritis (PsA) is a heterogeneous disease involving several musculoskeletal and extraarticular domains, including peripheral arthritis, enthesitis, dactylitis, axial disease, and skin and nail psoriasis. Each domain may contribute differently to disease burden and respond differently to treatment, making a treat-to-target strategy both essential and challenging.