Idiopathic multicentric Castleman disease (TAFRO subtype) can mimic common differentials. High suspicion is required for chronic systemic symptoms and generalized lymphadenopathy. As fine‐needle aspiration is often non‐diagnostic, early excisional biopsy is important. Rituximab‐based therapy represents a guideline‐supported alternative when anti‐IL‐6 treatment is unavailable or not feasible.
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Rohatgi et al. (2026) studied this question.
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