Data corrections (data normalization) for isotope analyses are crucial for traditional magnetic sector isotope ratio mass spectrometry to facilitate meaningful interlaboratory data comparisons. Within the nascent field of Orbitrap-IRMS (isotope ratio mass spectrometry by Orbitrap mass spectrometry) and particularly the application of Orbitrap-IRMS to the analysis of per- and polyfluoroalkyl substances (PFASs), data correction procedures do not exist. We present a procedure for correcting data generated during the analysis of PFASs by Orbitrap-IRMS. This procedure will provide for a robust comparison of data between laboratories.
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Wojtal et al. (2026) studied this question.
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