Key result
New essential hypertension linked to reduced cardiac parasympathetic reactivity, including ~0.17 lower E/I ratios.
Why the study?
Subtle impairments in cardiac parasympathetic reactivity often appear before overt cardiovascular complications in hypertension, a major global health concern.
Does essential hypertension reduce cardiac parasympathetic reactivity in newly diagnosed patients compared to healthy normotensive subjects?
Cross-Sectional (n=200)
No
Does essential hypertension reduce cardiac parasympathetic reactivity in newly diagnosed patients compared to healthy normotensive subjects?
Newly diagnosed essential hypertension is associated with significantly reduced cardiac parasympathetic reactivity, indicating early autonomic imbalance prior to overt cardiovascular complications.
aims- ANS (autonomic nervous system) is centre of cardiovascular regulation. Subtle impairments in parasympathetic branch of ANS; responses often appear before overt cardiovascular complications. Hypertension is a significant global health concern and major risk factor for cardiovascular complications. In this study primary the changes in cardiac parasympathetic reactivity in patients of essential hypertension and secondary difference of parasympathetic reactivity tests parameters in male and female were assessed. methods- A total of 200 participants; 100 newly diagnosed hypertensive and 100 healthy normotensive subjects included in this study. Data collection was started after prior ethical approval. Deep breathing (E/I ratio), lying to standing (30:15 ratio) and valsalva manoeuvre was assessed as parasympathetic tests parameters. Significance of difference in mean in both main groups and both subgroups were inferred by the student’s unpaired t-test. Statistical significance was assigned at p-value
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Sharma et al. (2026) conducted a cross-sectional in Essential Hypertension (n=200). Essential hypertension vs. Healthy normotensive subjects was evaluated on E/I ratio (heart rate response to deep breathing) (p=<0.001). Newly diagnosed patients with essential hypertension exhibited significantly reduced cardiac parasympathetic reactivity, including lower E/I ratios (1.12 vs 1.29, p<0.001), compared to normotensive subjects.
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