Key result
Transcatheter ASD closure reduces indexed RV end-diastolic dimension by ~0.5 cm/m2, especially in younger patients.
Why the study?
Does transcatheter closure of isolated secundum atrial septal defects improve right ventricular size in children, and what factors predict greater recovery?
Cohort (n=385)
No
Does transcatheter closure of isolated secundum atrial septal defects improve right ventricular size in children, and what factors predict greater recovery?
Answers are grounded in this paper and cite their sources.
Transcatheter ASD closure significantly reduces right ventricular volume overload in children, with greater remodeling seen in younger patients, supporting the potential clinical benefit of earlier intervention.
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Gritti et al. (2026) conducted a cohort in Isolated secundum atrial septal defects (n=385). Transcatheter device closure vs. Baseline (pre-intervention) was evaluated on Change in body surface area-indexed right ventricular end-diastolic dimension (RVEDDi) (p=<0.001). Transcatheter device closure of isolated secundum atrial septal defects significantly reduced right ventricular end-diastolic dimension from a baseline mean of 2.2 to 1.7 cm/m2 (p<0.001), with greater reductions seen in those treated at a younger age.
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