The cardiometabolic continuum: A new approach to prevention and care

Q: What is the clinical evidence from this study?

Study design: Editorial. Population: Cardiometabolic disorders.

Q: What does this research mean for the field?

Cardiometabolic disorders, including type 2 diabetes, hypertension, dyslipidemia, and obesity, accelerate atherosclerosis and contribute to cardiovascular disease being the leading cause of global mortality. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Kewal Krishan Talwar; SV Madhu

doi:10.25259/anams_223_2026

October 1, 2026Annals of the National Academy of Medical Sciences (India)Open Access

The cardiometabolic continuum: A new approach to prevention and care

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Key result

The editorial highlights the importance of the cardiovascular-kidney-metabolic (CKM) syndrome framework and advocates for an integrated, multidisciplinary approach to prevent and manage cardiometabolic diseases.

Key Points

To outline the evolving conceptual framework of the cardiometabolic continuum and emphasize early multidisciplinary prevention across cardiovascular, renal, and metabolic conditions.
Narrative review examining global cardiovascular mortality trends, clinical management guidelines, and pathophysiological pathways linking adiposity, insulin resistance, and cardiorenal disease.
Cardiovascular disease mortality has risen significantly over the last 3 decades, becoming the leading global cause of death with 2016 estimates reporting 17.9 million deaths, or every third death worldwide.
Cardiometabolic dysfunction progresses across a continuum starting with visceral adiposity, adiposopathy, and insulin resistance before progressing to diabetes, atherosclerosis, and congestive cardiac failure.
Clinical paradigms are shifting from glucose-centric targets toward comprehensive cardiorenal protection through multidisciplinary care, lifestyle modifications, and therapies including SGLT2 inhibitors and GLP-1 receptor agonists.

PICO

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Population

Cardiometabolic disorders

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Implication

This editorial emphasizes the importance of adopting the cardiovascular-kidney-metabolic (CKM) framework and integrated wellness approaches for the prevention and management of cardiometabolic diseases.

Abstract

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Cite This Study

Talwar et al. (2026) conducted an editorial in Cardiometabolic disorders. The editorial highlights the importance of the cardiovascular-kidney-metabolic (CKM) syndrome framework and advocates for an integrated, multidisciplinary approach to prevent and manage cardiometabolic diseases.

synapsesocial.com/papers/6ac19d70aeea5716e8c6c6c7 https://doi.org/10.25259/anams_223_2026

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The cardiometabolic continuum: A new approach to prevention and care

Key Points

PICO

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Implication

Abstract

Discussion

Cite This Study

The cardiometabolic continuum: A new approach to prevention and care

Key Points

PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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