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Several parameters of calcium and phosphate transport were measured in kidney cells at different medium phosphate concentrations and in the presence of PTH. Raising the medium phosphate from 0 to 10 mM increases calcium influx, the exchangeable calcium pool and the total cell calcium. The stimulation of calcium influx by PTH is obtained even in phosphatefree medium, whereas the expansion of the calcium pool cannot be obtained in the absence of external phosphate. PTH has no effect on the steady state phosphate influx and on the exchangeable phosphate pool. On the other hand, the total cell phosphate is increased by PTH but this effect is obtained only if calcium is present in the medium. Thus, the stimulation of calcium influx by PTH is independent of phosphate and is one of the primary effects of the hormone. (Endocrinology 86: 1389, 1970)
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A. B. Borle (1970) studied this question.
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