Serum Magnesium as a Prognostic Indicator in Acute Coronary Syndromes and Comparison With Coronary Prognostic Index

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Acute Coronary Syndromes (n=100). Intervention: Serum Magnesium levels. Primary outcome: Correlation of serum magnesium with Coronary Prognostic Index and arrhythmias.

ANNADATHA ACHYUTA AKHILESH; ANUJ VARMA; Kumar Sunil

doi:10.61841/wzvmjv94

August 31, 2020International Journal of Psychosocial RehabilitationOpen Access

Serum Magnesium as a Prognostic Indicator in Acute Coronary Syndromes and Comparison With Coronary Prognostic Index

View Full Paper

Ask AI

Bookmark

Share

Key result

Serum magnesium levels correlate with prognostic index and arrhythmia risk in acute coronary syndromes.

n=100

Why the study?

Electrolyte studies in Acute Coronary Syndromes have been conducted but no groundbreaking research has changed the management approach towards ACS and CHD involving serum magnesium.

Does serum magnesium level correlate with the Coronary Prognostic Index and arrhythmias in patients with acute coronary syndromes?

Key Points

To assess serum magnesium levels in patients with acute coronary syndromes and determine their correlation with the Coronary Prognostic Index and arrhythmias.
Planned enrollment of N=100 patients presenting within 12 hours of acute coronary syndrome symptom onset at a rural tertiary care center in Wardha between August 2019 and 2021.
Excluded patients with hypokalemia, hypercalcemia, malabsorption disorders, chronic alcoholism, or prior use of diuretics and long-term proton pump inhibitors.
Estimated serum magnesium levels within 72 hours of acute coronary syndrome presentation alongside electrocardiographic and cardiac marker evaluation for STEMI and NSTEMI.
Serum magnesium was identified as an important prognostic indicator in acute coronary syndromes.
Magnesium levels were linked to the risk of cardiac arrhythmias and aligned with bedside risk stratification via the Coronary Prognostic Index.

Study Design

Type

Observational (n=100)

Multicenter

No

Structured PICO

Does serum magnesium level correlate with the Coronary Prognostic Index and arrhythmias in patients with acute coronary syndromes?

P

Population

100 patients with acute coronary syndromes presenting within 12 hours of symptom onset to evaluate serum magnesium as a prognostic indicator.

O

Outcome

Correlation of Serum Magnesium levels with Coronary Prognostic Index and arrhythmiassurrogate

Serum magnesium levels may serve as a useful prognostic indicator in patients presenting with acute coronary syndromes.

Limitations

Thrombolysis in STEMI patients could lead to reperfusion and give false values of serum magnesium
The duration after the episode of ACS after which the sample was taken could make a difference in the values
Patients having Acute STEMI can undergo thrombolysis which would lead to reperfusion and give false values of serum magnesium if measured.
The duration after the episode of ACS after which the sample was taken could also make a difference in the values.

Implication

Serum magnesium may associate with ACS prognosis and arrhythmias; leaves open incremental value over coronary prognostic index pending quantitative validation.

Abstract

Coronary heart disease is one of the leading causes of morbidity and mortality in the world. Various risk factors at different levels have been extensively studied in this disease and various relationships of factors with the disease have been already been established. It is not far ahead by the time we start correlating new factors with CHD. Electrolyte studies in Acute Coronary Syndromes have been studied but there has been no ground breaking research which would change the approach towards managing a case of ACS and CHD (1-4). Serum Magnesium is second most major cation in the body with variety of functions in the body. Majority of the Serum Magnesium in the body is through the dietary sources and majority of the adults do not consume the average daily requirement of the same. Magnesium has been reported to cause arrhythmias and has a role in cardiac metabolism (5-10).

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

AKHILESH et al. (2020) conducted an observational in Acute Coronary Syndromes (n=100). Serum Magnesium levels was evaluated on Correlation of serum magnesium with Coronary Prognostic Index and arrhythmias. Serum magnesium was reported to be an important prognostic indicator in acute coronary syndromes, though no quantitative data were provided in the text.

synapsesocial.com/papers/6ac1ab93cc6172083c9289af https://doi.org/10.61841/wzvmjv94

View Full Paper

Ask AI

Bookmark

Share

Serum Magnesium as a Prognostic Indicator in Acute Coronary Syndromes and Comparison With Coronary Prognostic Index

Key Points

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

Serum Magnesium as a Prognostic Indicator in Acute Coronary Syndromes and Comparison With Coronary Prognostic Index

Key Points

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading