Key result
Low serum magnesium (≤0.80 mmol/L) was associated with an increased risk of coronary heart disease mortality (HR 1.36; 95% CI 1.09-1.69) and sudden cardiac death (HR 1.54; 95% CI 1.12-2.11).
Why the study?
Is low serum magnesium associated with an increased risk of coronary heart disease mortality and sudden cardiac death in a general population cohort?
Population
9,820 participants from the prospective population-based Rotterdam Study, mean age 65.1 years, 56.8% female
Comparison
Low serum magnesium (≤0.80 mmol/L) vs Normal serum magnesium
Design
Cohort
Follow-up
median 8.7 years
Authors
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Low magnesium associated with higher CHD mortality/SCD; hypothesis-generating and requires RCTs before informing supplementation.
Cohort (n=9,820)
Is low serum magnesium associated with an increased risk of coronary heart disease mortality and sudden cardiac death in a general population cohort?
Effect estimate: HR 1.36 (95% CI 1.09-1.69)
Low serum magnesium is an independent risk factor for coronary heart disease mortality and sudden cardiac death in the general population.
Kieboom et al. (2016) conducted a cohort in Coronary heart disease and sudden cardiac death (n=9,820). Low serum magnesium vs. 0.81-0.88 mmol/L was evaluated on Coronary heart disease mortality (HR 1.36, 95% CI 1.09-1.69). Low serum magnesium (≤0.80 mmol/L) was associated with an increased risk of coronary heart disease mortality (HR 1.36; 95% CI 1.09-1.69) and sudden cardiac death (HR 1.54; 95% CI 1.12-2.11).
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