Salmonella Typhi: Virulence, Multi drug Resistance and Vaccines

Typhoid is an important acute systemic illness affecting human beings globally and especially in developing countries of Asia and Africa. The disease leads to millions of deaths and heavy economic loss annually worldwide. The causative agents of typhoid are Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi. In the present review, we have discussed about the virulence of S. Typhi, emergence of multiple drug resistance in Salmonella, which has made the treatment of typhoid fever more complicated and the various vaccines used to control the Salmonella infection. In present scenario, there is an urgent need of effective and safe vaccines for S. Typhi as the current available vaccines are having certain limitations.