Key result
Alpha2cDel322-325 variant linked to ~64% lower odds of DCM heart failure.
Why the study?
The correlation of adrenergic receptor polymorphisms alpha(2c)Del322-325, beta(1)Ser49Gly, and beta(1)Arg389Gly with heart failure risk in the Japanese population was unclear.
Case-Control
No association seen with these polymorphisms in Japanese DCM; leaves open relevance in other populations or larger studies.
AIMS: We investigated the correlation of adrenergic receptor polymorphisms, alpha(2c)Del322-325, beta(1)Ser49Gly and beta(1)Arg389Gly, with the risk of heart failure in the Japanese population. METHODS: These polymorphisms were analysed by polymerase chain reaction-restriction fragment length polymorphism in patients with chronic heart failure due to idiopathic dilated cardiomyopathy (DCM) and compared with the control group. RESULTS: There were no differences or any trends in the allele and genotype frequencies of the beta(1)Ser49Gly and beta(1)Arg389Gly polymorphisms. The allele frequency of the alpha(2c)Del322-325 variant was lower in patients than in controls (0.11 vs. 0.04, P = 0.011 < 0.017, by Bonferroni correction), while the genotype frequency just failed to reach significance (P = 0.022 > 0.017, by Bonferroni correction). CONCLUSIONS: In this population, the variants beta(1)Ser49, beta(1)Arg389, and alpha(2c)Del322-325 do not appear to be risk factors for chronic heart failure due to DCM. The alpha(2c)Del322-325 variant may in fact confer some protection.
No takes yet. Share an insight, caveat, or question.
Nonen et al. (2005) conducted a case-control in chronic heart failure due to idiopathic dilated cardiomyopathy. adrenergic receptor polymorphisms (alpha(2c)Del322-325, beta(1)Ser49Gly and beta(1)Arg389Gly) vs. control group was evaluated on allele and genotype frequencies of adrenergic receptor polymorphisms (p=0.011). The alpha(2c)Del322-325 variant allele frequency was lower in patients with heart failure due to DCM than in controls (0.04 vs. 0.11, P=0.011), suggesting it may confer some protection.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: