Real-life cow’s milk immunotherapy at 15 years: what do these numbers represent? Comment on: Cow's milk oral immunotherapy in real-life: up to 15-year follow-up study - doi:10.23822/EurAnnACI.1764-1489.424)

Key wordsCow's milk allergy; oral immunotherapy; eosinophilic esophagitis; long-term follow-up.Gaspar and colleagues report a much-needed extension of their group's long-standing experience with cow's milk oral immunotherapy (CM-OIT), now following 33 children for as long as fifteen years (1).Complete desensitization was achieved in the large majority of patients, though maintenance was far from uneventful: four in five children reacted at some point, a third experienced anaphylaxis, and eosinophilic esophagitis (EoE) was newly identified in roughly one in eight.This is a genuinely rare dataset, and the authors deserve credit for keeping families in follow-up this long.A few aspects of the report, however, would benefit from further explanation.