An interdisciplinary framework integrating management, global occupational health, and neuroscience for workplace well-being

Workplace well-being is a critical determinant of global public health and organizational productivity. Despite awareness of psychosocial risks and mental health in workplace, issues such as presenteeism, burnout, and chronic non-communicable diseases (NCDs) continue to rise. We propose a multidisciplinary, theoretical framework that integrates organizational management, global occupational health, neuroscience, and positive psychology to assess and improve workplace environments, thereby benefiting both individual health and the common good. The goal is to foster effective, healthy, and efficient work. Global occupational health supports the systematic assessment of workers’ capacities and vulnerabilities, the early identification of psychosocial risks, and the prevention of chronic NCDs across diverse working populations. Basic and applied neuroscience address the complexity of human emotions and cognition with their underlying neural mechanisms. Evidence clarifies the neural circuits underpinning feelings, motivation, stress responses, and interindividual variability in coping with stress and job demands. Positive psychology research provides non-pharmacological strategies—such as mindfulness, strengths-based approaches, and gratitude or meaning-centered interventions—that might reduce distress and enhance resilience when implemented according to scientific and ethical standards. Integrating these domains allows policymakers, stakeholders, managers, occupational health professionals, and workers to design multi-level interventions that improve decision-making and promote healthier organizations. Such an interdisciplinary approach offers a promising pathway to protect and promote workers’ well-being by designing evidence-informed strategies to prevent workplace-related mental disorders, accidents, and avoidable mortality.