With the increasing use of psychedelics in both clinical and non-clinical contexts, there is growing potential for harm arising from challenging experiences and post-psychedelic difficulties. This qualitative review aimed to explore psychedelic users’ experiences of acute and post-psychedelic challenges in non-clinical contexts, to identify practice considerations for safer and more effective client work supporting the evolving role of counselling psychologists and practitioners in related fields. A comprehensive search across EBSCO databases and Google Scholar identified seven studies (n = 721) published between 2021 and 2025. Data extraction, quality appraisal, and meta-aggregative synthesis were conducted in accordance with JBI methodology. Four synthesised findings were identified: (1) complex experiences of distress; (2) diverse and individualised coping strategies; (3) external support and challenges; and (4) internal adjustment and ambiguous outcomes. Findings indicate that experiences are varied, complex, and paradoxical; this highlights the value of pluralistic harm-reduction approaches that acknowledge diversity of experience to ensure safer and more effective outcomes for those navigating post-psychedelic difficulties.
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Grimshaw et al. (2026) studied this question.
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