What question did this study set out to answer?

To determine how biosynthetic reaction networks control mass-dependent fractionations of multiple sulphur isotopes and evaluate their utility in identifying specific microbial metabolisms in the geological record.

July 1, 2003Geobiology

Multiple sulphur isotopic interpretations of biosynthetic pathways: implications for biological signatures in the sulphur isotope record

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To determine how biosynthetic reaction networks control mass-dependent fractionations of multiple sulphur isotopes and evaluate their utility in identifying specific microbial metabolisms in the geological record.
Modeled multi-step biochemical reaction networks involved in dissimilatory sulphate reduction.
Reanalyzed experimental multiple-sulphur-isotope data (δ33S and δ34S) from the sulphate-reducing archaeon Archaeoglobus fulgidus using network flow models.
Material flow across enzymatic networks generated distinct multiple-sulphur-isotope signatures that differed from individual constituent biochemical steps.
The sensitivity of sulphur isotope fractionation to external sulphate concentrations was traced to imbalances between forward and reverse adenosine-5′-phosphosulphate reaction steps.
Paired measurements of δ33S and δ34S successfully resolved pathways of sulphate reduction from disproportionation reactions.

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Implication

Biochemical modeling reveals how metabolic reaction networks govern multiple sulphur isotope fractionations in Archaeoglobus fulgidus, indicating ways to identify ancient microbial pathways.

Cite This Study

Farquhar et al. (2003) studied this question.

synapsesocial.com/papers/6ac1fb210344bbefaef069e0 https://doi.org/10.1046/j.1472-4669.2003.00007.x

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Implication

Biochemical modeling reveals how metabolic reaction networks govern multiple sulphur isotope fractionations in Archaeoglobus fulgidus, indicating ways to identify ancient microbial pathways.

Multiple sulphur isotopic interpretations of biosynthetic pathways: implications for biological signatures in the sulphur isotope record

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Discussion

Implication

Cite This Study

Multiple sulphur isotopic interpretations of biosynthetic pathways: implications for biological signatures in the sulphur isotope record

Key Points

Discussion

Implication

Cite This Study

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