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Induction of an efficient type I IFN response is important to control viral infection. We show that the host 2′- O -methyltransferase CMTR1 facilitates the protein expression of ISGs in human cells by preventing IFIT1 from inhibiting the translation of those mRNAs lacking cap 2′- O -methylation. Thus, CMTR1 promotes the IFN-mediated antiviral response.
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Williams et al. (2020) studied this question.
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