Key result
AF-related SNPs show no significant association with left atrial size or volume.
Why the study?
Whether genetic variants associated with atrial fibrillation are also associated with atrial structure, an intermediate phenotype for AF, has had limited investigation.
Cross-Sectional (n=6,951)
Single-blind
No
p-value: p=>0.0023
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AF SNPs unrelated to LA size suggest non-structural mediation of risk; leaves open alternative pathways for genetic studies.
Magnani et al. (2014) conducted a cross-sectional in Atrial Fibrillation Genetic Risk (n=6,951). 11 Atrial Fibrillation-associated single nucleotide polymorphisms (SNPs) vs. Reference alleles was evaluated on Cross-sectional left atrial dimensions (LA diameter by echocardiography and LA volume by cardiovascular magnetic resonance) (p=>0.0023). In a community-based cohort, 11 selected single nucleotide polymorphisms associated with atrial fibrillation were not significantly associated with cross-sectional measures of left atrial volume or diameter.
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