Green route synthesis of Schiff's bases of isonicotinic acid hydrazide

Imines constitute a class of therapeutic agents that possess a broad spectrum of pharmacological activity. The conventional method for synthesis of imines by nucleophilic addition of amines to ketones or aldehydes requires long reaction times along with the use of organic solvents and a glacial acetic acid catalyst. We report the synthesis of Schiff's bases of isonicotinic acid hydrazide by novel, green routes using sonication, stirring, and microwave irradiation, respectively. Initial results are reported and indicate that by employing greener methods under aqueous conditions, high yields and shorter reaction times can be achieved.