What is the clinical evidence from this study?

Study design: Cohort. Population: Severe Mitral Regurgitation (n=192). Intervention: Mitral valve repair. Primary outcome: Actuarial survival at mean 43 months.

What does this research mean for the field?

Mitral valve repair yields excellent midterm survival and low reoperation rates in severe mitral regurgitation, though ischemic etiology, low preoperative ejection fraction, and advanced residual NYHA class independently predict mortality. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess early and midterm clinical outcomes of mitral valve repair and determine independent predictors of mortality and reoperation.

October 5, 2026Progress in nutritionOpen Access

Evaluation of Early and Midterm Mitral Valve Repair Results in Consecutive Severe Mitral Regurgitation Patients

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Key result

Mitral valve repair for severe mitral regurgitation achieves ~96% mid-term survival with low operative mortality.

n=192

Why the study?

Surgical mitral valve repair has advantages over replacement, but independent risk factors affecting early and mid-term outcomes need investigation.

Key Points

To assess early and midterm clinical outcomes of mitral valve repair and determine independent predictors of mortality and reoperation.
Retrospective single-center review of N=192 consecutive adult patients (mean age: 43.2±12.3 years; 120 females, 72 males) undergoing primary mitral valve repair between January 2012 and July 2018 in Turkey.
Surgical techniques included annuloplasty band (73.4%) or ring (25.5%) placement, edge-to-edge repair (23.4%), and leaflet resections, with a mean follow-up of 41±18 months.
Operative mortality was 2.6% (5/192 deaths within 0–30 days postoperatively) and late mortality was 3.7% (7/187), with Kaplan–Meier actuarial survival of 95.8%±2.3% at 43 months and reoperation-free survival of 92.8%±4.2% at 60 months.
Independent predictors of mortality on multivariate analysis were residual NYHA class III/IV (OR 2.53, 95% CI: 1.93–4.88, p=0.023), low preoperative ejection fraction (OR 3.11, 95% CI: 1.82–5.66, p=0.001), and ischemic MR (OR 3.39, 95% CI: 1.29–4.37, p=0.01).
Reoperation occurred in 16 patients (8.3%) and was independently predicted by persistent mitral regurgitation at postoperative day 3 (OR 3.55, 95% CI: 1.55–5.5, p=0.001) and absence of a prosthetic ring or band (OR 4.55, 95% CI: 1.58–7.18, p=0.001).

Study Design

Type

Cohort (n=192)

Multicenter

Structured PICO

Population

192 consecutive adult patients with severe mitral regurgitation who underwent primary mitral valve repair, followed for a mean of 41 months.

Intervention

Primary mitral valve repair using various techniques (including annuloplasty ring or band insertion, edge-to-edge repair, quadrangular/triangular resection, and neochord insertion) performed under cardiopulmonary bypass.

Outcome

Early and mid-term outcomes including operative mortality (0-30th postoperative day), late mortality, and need for re-operation.hard clinical

Mitral valve repair for severe mitral regurgitation demonstrates excellent mid-term survival and low reoperation rates, though ischemic etiology and low preoperative ejection fraction predict higher mortality.

Limitations

Retrospective design
Single-center study
Lack of a direct comparator group

Implication

May support repair feasibility in younger severe MR patients; leaves open need for randomized confirmation of predictors and durability.

Abstract

Study Objectives: Surgical valve repair for mitral regurgitation has significant advantages over valve replacement. In this study, we aimed to investigate the early and mid-term results of mitral valve repair using current techniques in order to find out independent risk factors affecting the early and mid-term outcomes. Methods: We retrospectively studied firstly 192 consecutive adult patients (mean age: 43.2±12.3; 120 females and 72 males) who underwent primary mitral valve repair between January 2012 and July 2018. Risk factors affecting the need for re-operations and late survival were determined via univariate and multivariate analyses. Actuarial survival and event-free curves were compared by linear regression analysis. Results: Operative mortality was 2.6% (5 deaths 0–30th. postoperative day (POD). Late mortality was 3.7% (7/187). Reoperation was required in 16 (8.3%) patients. Kaplan–Meier actuarial survival was 95.8%±2.3% at a mean of 43 months. Survival free from reoperation was 92.8%± 4.2% at 60 months. Multivariate analysis demonstrated that residual NYHA class III and IV, low preoperative ejection fraction, and ischemic MR were independent predictors of mortality. Conclusion: We concluded that mitral valve repair showed excellent survival (except ischemic MR), acceptable re-operation rate with satisfactory valve function in a mid-term follow-up period.

Discussion

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Cite This Study

Uygur et al. (2022) conducted a cohort in Severe Mitral Regurgitation (n=192). Mitral valve repair was evaluated on Actuarial survival at mean 43 months. Mitral valve repair in patients with severe mitral regurgitation demonstrated an operative mortality of 2.6% and an actuarial survival of 95.8% at a mean follow-up of 43 months.

synapsesocial.com/papers/6ac2eef270c065e257f28dc1 https://doi.org/10.23751/pn.v24is1.12879

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Implication

May support repair feasibility in younger severe MR patients; leaves open need for randomized confirmation of predictors and durability.

Evaluation of Early and Midterm Mitral Valve Repair Results in Consecutive Severe Mitral Regurgitation Patients

Key Points

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

Evaluation of Early and Midterm Mitral Valve Repair Results in Consecutive Severe Mitral Regurgitation Patients

Key Points

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

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